Document 0105
 DOCN  M9490105
 TI    [Ensuring the safety of erythrocyte concentrates using quarantine]
 DT    9411
 AU    Majorel-Riviere H; Centre de Transfusion Sanguine, Valence.
 SO    Transfus Clin Biol. 1994;1(3):197-207. Unique Identifier : AIDSLINE
       MED/94319516
 AB    We have decided that it is essential to establish a process to protect
       patients receiving concentrated red blood cells (CGR) from a residual
       risk of contamination by the HIV virus or by the hepatitis C virus.
       Viral inactivation techniques of labile blood products are not presently
       in use, only safety measures obtained by quarantine allow a reduction of
       this risk to a value approaching 0. We have developed, from known
       deep-freeze methods of red blood corpuscles, a process to place the
       samples of concentrated red blood cells in quarantine by means of
       deep-freezing. We have modified and automated the deep-freezing, thawing
       and washing manipulations of the red blood corpuscles in order to obtain
       a final product which is standardized in quantity and quality. The
       result of our work will show: That all the means employed are not a
       source of contamination of the end product. That the procedures employed
       may be easily adapted to all Blood Transfusion Centers. That the
       end-product may be used after 21 days of conservation. That the extra
       cost entailed by this procedure is realistic.
 DE    *Cryopreservation/STANDARDS  English Abstract
       Erythrocytes/*MICROBIOLOGY  Human  Quality Assurance, Health Care  Risk
       Factors  Sterilization  JOURNAL ARTICLE

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